Pure red cell aplasia as possible early manifestation of chronic myeloid leukemia
作者:
Oskar A. Haas,
Wolfgang Hinterberger,
Reinhard Mörz,
期刊:
American Journal of Hematology
(WILEY Available online 1988)
卷期:
Volume 27,
issue 1
页码: 20-25
ISSN:0361-8609
年代: 1988
DOI:10.1002/ajh.2830270106
出版商: Wiley Subscription Services, Inc., A Wiley Company
关键词: Philadelphia chromosome;erythroid progenitors;myeloid progenitors
数据来源: WILEY
摘要:
AbstractCytogenetic studies as well as erythroid and myeloid progenitor cell assays were performed in a 29‐yr‐old epileptic man with pure red cell aplasia (PRCA) who had been treated with primidone for several years. Despite clinical evidence of preleukemia, our studies indicated an underlying atypical Philadelphia chromosome‐positive myeloproliferative disorder. These laboratory findings were confirmed by the subsequent development of chronic myeloid leukemia (CML) which terminated in a CALLA‐positive lymphoblastic crisis 32 months later.The rare concurrent occurrence of PRCA and CML and the possible inducing role of the preceding antiepileptic treatment are di
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