Quantitavive Proton Magnetic Resonance Analysis of Ranitidine in Solid Dosage Forms
作者:
Tuncel Özden,
Ahmet Üngörmüş,
Ali Tosun,
Seyhan Ersan,
期刊:
Spectroscopy Letters
(Taylor Available online 1997)
卷期:
Volume 30,
issue 5
页码: 835-841
ISSN:0038-7010
年代: 1997
DOI:10.1080/00387019708001632
出版商: Taylor & Francis Group
关键词: PMR Analysis;Ranitidine
数据来源: Taylor
摘要:
A rapid and specific proton magnetic resonance (PMR) spectroscopic method was developed for determining ranitidine hydrochloride in tablets. 2-Choloroacetophenon was used as the internal standard and DMSO-d6served as the PMR solvent. The concentration of drug per unit dose was calculated from the integration values for the resonance signals of ranitidine hydrochloride at 4.32 δ ppm and int. st. at 5.19 δ ppm. The method using commercial products gave comparable results to those obtained by the methods of UV spectroscopy and USP XXIII.
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