Complementation and Phenotypic Stabilization of Vesicular Stomatitis Virus Temperature-Sensitive and Thermolabile Mutants by Avian Myeloblastosis Virus
作者:
Jan Závada,
Eva Závodská,
期刊:
Intervirology
(Karger Available online 1973)
卷期:
Volume 2,
issue 1
页码: 25-32
ISSN:0300-5526
年代: 1973
DOI:10.1159/000149401
出版商: S. Karger AG
关键词: Complementation;Phenotypic mixing;Pseudotypes;Oncornavirus;Rhabdovirus
数据来源: Karger
摘要:
Out of five complementation groups of vesicular stomatitis virus (VSV) type Indiana, each represented by two temperature-sensitive (ts) mutants, only representatives of group V showed genetic complementation by avian myeloblastosis virus Pseudotypes (AMV); the VSV (AMV) appeared among the progeny. Thermolabile (tl) mutants with apparently defective glycoprotein were phenotypically stabilized by growth in the presence of AMV, but a tl mutant with a defect in some other structural protein was not. Mutants with a tl glycoprotein and a ts defect corresponding to complementation group I were phenotypically stabilized by growth in the presence of AMV, but did not show genetic complementation by AMV.
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