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Visual disorders associated with omeprazole and their relation to CYP2C19 polymorphism

 

作者: Markus Lutz,   Matthias Schwab,   Ernst-Ulrich Griese,   Claudia Marx,   Bruno Müller-Oerlinghausen,   Peter Schönhöfer,   Christoph Meisner,   Christoph Gleiter,   Michel Eichelbaum,   Klaus Mörike,  

 

期刊: Pharmacogenetics  （OVID Available online 2002）
卷期: Volume 12, issue 1  

页码: 73-75

 

ISSN:0960-314X

 

年代: 2002

 

出版商: OVID

 

数据来源: OVID

 

摘要:

Risk factors for patients developing visual disturbances in association with proton pump inhibitors are unknown. As omeprazole is substantially metabolized by polymorphic CYP2C19, we retrospectively identified and genotyped patients who experienced this adverse reaction. Among 29 patients, we found two poor metabolizers (PMs) of CYP2C19. The PM genotype does not appear to be a risk factor for omeprazole-associated visual disorders.

 

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