This report is an exploratory study of the information needs and information seeking in a sample of nurse practitioners (NPs) approved to practice in North Carolina. A search and review of relevant literature revealed no studies on this topic. In this study, NPs report thier most frequent information needs relate to drug therapy, diagnosis, and other therapy. Their most frequently used information resources are physicians, drug reference manuals, and textbooks. They most frequently confer with physicians on diagnosis and other therapy and other NPs on psychosocial issues.