Inhibitory Effect of Bifemelane on Superoxide Generation by Activated Neutrophils Measured Using a Simple Chemiluminescence Method
作者:
YoshidaToshihiko,
SotomatsuAkemi,
TanakaMakoto,
HiraiShunsaku,
期刊:
Free Radical Research
(Taylor Available online 1994)
卷期:
Volume 21,
issue 6
页码: 371-376
ISSN:1071-5762
年代: 1994
DOI:10.3109/10715769409056589
出版商: Taylor&Francis
关键词: Bifemelane hydrochloride;superoxide;MCLA-dependent chemiluminescence assay;activated neutrophils
数据来源: Taylor
摘要:
We evaluated the effect of 4-(2-benzylphenoxy)-N-methylbutylamine hydrochloride (bifemelane hydrochloride) on superoxide production by human neutrophils using an MCLA-dependent chemiluminescence assay. Bifemelane hydrochloride dose-dependently inhibited superoxide production by neutrophils stimulated with phorbol myristate acetate, opsonized zymosan, or N-formyl-methionyl-leucyl-pheny-lalanine, while it had no effect on superoxide production by a hypoxanthine-xanthine oxidase system. These results indicate that bifemelane hydrochloride does not have a scavenging effect, but has an inhibitory effect on superoxide generation by neutrophils. Although this drug is commonly used for treating chronic cerebral infarction, it may also have a protective effect on acute ischemia/reperfusion injury.
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