Evaluation of the rat tail model for estimating dermal absorption of lindane
作者:
RichardP. Moody,
Michael Grayhurst,
Len Ritter,
期刊:
Journal of Toxicology and Environmental Health
(Taylor Available online 1989)
卷期:
Volume 28,
issue 3
页码: 317-326
ISSN:0098-4108
年代: 1989
DOI:10.1080/15287398909531352
出版商: Taylor & Francis Group
数据来源: Taylor
摘要:
Dermal absorption of the insecticide lindane was determined following topical application of ring14C‐labeled lindane to the tail of Sprague‐Dawley rats. The tail was tested as a practical alternative to the rat mid‐dorsal (back) region, and the data obtained were compared to those with rat back and with those of rhesus monkeys in our previous reports. There was no significant difference between total percentage urinary14C recovery for rats dosed on the tail with occlusive tail covers (52 ± 6.2%tv2= 2.7 d) compared to those with nonocclusive covers (55 ± 4.4%tv2= 2.9 d). Neither the total percentage urinary recovery nor the t1/2values obtained for the rat tail and rat back models differed significantly. Carbon‐14 activity was still detectable in urine samples taken after 72 d post‐treatment. However, an extensive tissue analysis failed to demonstrate14C activity persisting at 72 d, with the exception of trace levels detected in blood serum and tail tissue. Advantages of the rat tail model are highlighted.
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