Biochemical cure of recurrent acromegaly by resection of cervical spinal canal metastases
作者:
Colin Dayan,
Tess Guilding,
Stephen Hearing,
Paul Thomas,
Richard Nelson,
Tim Moss,
John Bradshaw,
Andy Levy,
Stafford Lightman,
期刊:
Clinical Endocrinology
(WILEY Available online 1996)
卷期:
Volume 44,
issue 5
页码: 597-602
ISSN:0300-0664
年代: 1996
DOI:10.1046/j.1365-2265.1996.685507.x
出版商: Blackwell Science Ltd
数据来源: WILEY
摘要:
Pituitary carcinoma with metastatic endocrine secreting tissue is rare. Eight cases of malignant, growth hormone‐secreting tumours, all metastatic within the central nervous system have been previously described. Complete surgical resection was not possible and the patients died within 4 years of presentation with distant spread. Here we describe the first case of an apparent surgical cure of a somatotroph carcinoma metastatic to the cervical spine, documented by biochemical assessment and magnetic resonance and radioligand imaging. The possibility that intrathecal metastasis of somatotroph tumours may be responsible for some cases of treatment resistant acromegaly is discusse
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