Modification of coronary artery disease progression by cholesterol‐lowering therapythe angiographic studies
作者:
R. Archbold,
Adam Timmis,
期刊:
Current Opinion in Lipidology
(OVID Available online 1999)
卷期:
Volume 10,
issue 6
页码: 527-534
ISSN:0957-9672
年代: 1999
出版商: OVID
数据来源: OVID
摘要:
Large randomized placebo-controlled trials have demonstrated that cholesterol lowering with statin therapy reduces the incidence of adverse cardiac events. Smaller angiographic studies have shown that coronary artery disease progression can be slowed and, in some cases, reversed by cholesterol-lowering interventions. These anatomical changes, however, are small and occur too slowly to account for the early clinical benefit. Current evidence suggests that plaque stabilization is the most important mechanism, by which cholesterol-lowering therapy reduces both the incidence of adverse cardiac events and coronary artery disease progression.
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