首页   按字顺浏览 期刊浏览 卷期浏览 Ontogeny of the Immune System and the Invisible Frontier to Immune Regulation
Ontogeny of the Immune System and the Invisible Frontier to Immune Regulation

 

作者: ZanettiMaurizio,  

 

期刊: International Reviews of Immunology  (Taylor Available online 1992)
卷期: Volume 8, issue 2-3  

页码: 209-218

 

ISSN:0883-0185

 

年代: 1992

 

DOI:10.3109/08830189209055574

 

出版商: Taylor&Francis

 

关键词: autoantibodies;neonatal repertoire;idiotype;CD45;T cell activation;regulation

 

数据来源: Taylor

 

摘要:

The data presented focus on three topics: 1) Self-reactivity of early B cells as a constitutive feature of the immune system; 2) Self-reactive V regions and their possible involvement in immune regulation; and 3) Autoantibodies directed at T cell surface molecules as a new form of direct regulation of the B cell repertoire on the T cell compartment. Evidence is provided for lack of substantial difference in the reactivity of neonatal hybridomas from normal and autoimmune mice, and the proposal is made that the immune systems of normal and autoimmune neonatal mice start with similar characteristics implying that avoidance of autoimmune disease is matter of active regulation through a process learned in ontogeny. Two general possibilities for immune regulation are discussed. One is based on the V regions of self-reactive antibodies and their antigenic determinants. The other is through natural autoantibodies able to interfere with the state of activation of T cells. It is concluded that the role of highly conserved structures like self antigens is to maintain immunoglobulin genes and favor their expression in the incipient immune system so that simple patterns of regulation can be set in motion and made available.

 

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