Phase II Trial of Ifosfamide, Fluorouracil, and Folinic Acid (FIFO Regimen) in Relapsed and Refractory Urothelial Cancer
作者:
KattanJoseph,
CulineStéphane,
TheodoreChristine,
PierreJean,
期刊:
Cancer Investigation
(Taylor Available online 1995)
卷期:
Volume 13,
issue 3
页码: 276-279
ISSN:0735-7907
年代: 1995
DOI:10.3109/07357909509094462
出版商: Taylor&Francis
数据来源: Taylor
摘要:
There is no known effective salvage chemotherapy for patients with refractory or relapsed urothelial tumors after methotrexate/cisplatin-based regimen. We report the results of a phase II trial with the FIFO regimen that includes from day 1 to 5: jluorouracil 350 mg/m2,folinic acid 20 mg/m2, and ifosfamide 1000 mg/m2,Q4W. Fifteen patients with metastatic measurable urothelial cancer were enrolled in this trial. Previous therapy included M-VAC regimen in 11 patients, CMV regimen in 3 patients, and both regimens in 1 patient. Thirty-one courses were delivered. Toxicity was moderate, including encephalopathy grade 2 in 2 patients and hematological toxicity grade 3 in 2 others. However, an early death occurred on day 1 in a patient who progressed rapidly and died from hepatic insuflciency after initial encephalopathy. No objective response was seen. Twelve patients progressed during FIFO therapy and 3 patients experienced a stable disease. Despite almost encouraging results of fluorouracil and ifosfamide in the literature, their combination according to our schedule is not active in urothelial cancer.
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