Involvement of Dopamine D1Receptors in Phencyclidine‐Induced Behavioral Stimulation in Rats
作者:
Tetsuyuki Tsutsumi,
Makoto Hirano,
Takashi Matsumoto,
Kaoru Nakamura,
Kijirou Hashimoto,
Hisao Hondo,
Yuji Yonezawa,
Akira Tsukashima,
Hiroshi Nakane,
Hideyuki Uchimura,
Tatsuo Nakahara,
期刊:
Clinical Neuropharmacology
(OVID Available online 1995)
卷期:
Volume 18,
issue 1
页码: 64-71
ISSN:0362-5664
年代: 1995
出版商: OVID
关键词: Phencyclidine;Dopamine D1receptor;Dopamine D2receptor;Locomotor activity;Stereotyped behavior.
数据来源: OVID
摘要:
The effects of dopamine receptor antagonists on phencyclidine (PCP)-induced behaviors were examined in rats. Acute administration with PCP (7.5 mg/kg i.p.) produced various behavioral changes, such as increases of spontaneous activity, head-weaving, sniffing, rearing, back-pedaling, and ataxia. To determine which dopamine receptor subtypes were involved in mediating the PCP-induced behaviors. SCH 23390 (0.05 and 0.5 mg/kg), sulpriride (20 and 100 mg/kg), or haloperidol (0.05 and 0.5 mg/kg) were pretreated 30 min before PCP treatment (7.5 mg/kg). A higher dose of SCH 23390 significantly reduced the increase of spontaneous activity induced by PCP. Both doses of sulpiride did not affect the PCP-induced behaviors. A higher dose of haloperidol decreased the PCP-induced spontaneous activity, wherease a lower dose of haloperidol enhanced the activity. Ketanserin (0.5 and 5 mg/kg) did not alter any PCP-induced behaviors. These results suggest that the D1, but not D2, dopamine receptor subtype may be involved in the PCP-induced behavioral abnormality.
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