Identification of potential fish carcinogens in sediment from hamilton harbour, ontario, canada
作者:
G.C. Balch,
C.D. Metcalfe,
S.Y. Huestis,
期刊:
Environmental Toxicology and Chemistry
(WILEY Available online 1995)
卷期:
Volume 14,
issue 1
页码: 79-91
ISSN:0730-7268
年代: 1995
DOI:10.1002/etc.5620140110
出版商: Wiley Periodicals, Inc.
关键词: Carcinogens;Mutagens;Tumors;Sediments;PAHs
数据来源: WILEY
摘要:
AbstractA carcinogenicity‐ and mutagenicity‐directed fractionation approach was used to identify the carcinogenic compounds in contaminated sediments that are putatively responsible for the high prevalence of tumors in bottom‐dwelling fish from Hamilton Harbour, Ontario. Mutagenic activity was detected with Ames tester strains (TA98, TA100) in relatively nonpolar fractions of sediment extract containing PAHs and nitrogen‐containing aromatic compounds (NCACs). These fractions were also carcinogenic in an in vivo carcinogenicity bioassay with rainbow trout (Oncorhynchus mykiss). When a more polar extract fraction was tested for mutagenicity and carcinogenicity, weak mutagenic activity was detected with anO‐acetyltransferase‐enriched Ames tester strain (YG1024), and weak carcinogenic activity was detected in the rainbow trout assay. These data indicate that PAHs in contaminated Hamilton Harbour sediments are potent fish carcinogens, but it is also evident that other organic compounds in the sediment, such as NCACs and nitroarenes, may contribute to carc
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