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Growth Promoting Activity of PDGF, EGF and TGF-βon Highly Metastatic Subline of Meth a Cells

 

作者: NiitsuYoshiro,   KoshidaYoshikazu,   MaharaKatsuo,   IshigakiSeishi,   KogawaKatsuhisa,   WatanabeNaoki,   UrushizakiYoichi,   KongoYutaka,   UrushizakiIchiro,  

 

期刊: Immunopharmacology and Immunotoxicology  (Taylor Available online 1988)
卷期: Volume 10, issue 1  

页码: 67-78

 

ISSN:0892-3973

 

年代: 1988

 

DOI:10.3109/08923978809014402

 

出版商: Taylor&Francis

 

数据来源: Taylor

 

摘要:

AbstractThe response of a highly metastatic cell line of methylcholanthrene induced A fibrosarcoma (Meth A) to growth factors from platelets was examined. The highly metastatic cell subline (MH) proliferated more rapidly than its parental counterpart cell subline (ML) in a medium containing platelet lysate. However, when the three major growth factors from platelets, ie, platelet-derived growth factor, epidermal growth factor, and transforming growth factor-β(PDGF, EGF, TGF-β), were independently examined for their growth promoting activity, the former 2 growth factors preferentially stimulated the proliferation of ML and the latter growth factor rather suppressed the growth of both cells.On the other hand, the combined effects of these factors were more marked on MH. This combination effect was supported by the evidence that the number of receptors for EGF (which is probably an essential growth factor for the Meth A cell) was increased by pretreatmenl with PDGF or TGF-β. Thus, the highly metastatic cells of MH were considered to be the most susceptible to growth factors released from platelets. This conclusion is consistent with the concept that platelets may play an important role in the formation of blood-borne metastasis by releasing growth factors to promote the proliferation of tumor cells, following aggregation with tumor cells.

 

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