Facile and high yielding syntheses of phosphatidylcholines and phosphatidylethanolamines containing2H‐labeled acyl chains
作者:
B. Perly,
Erick J. Dufourc,
Harold C. Jarrell,
期刊:
Journal of Labelled Compounds and Radiopharmaceuticals
(WILEY Available online 1984)
卷期:
Volume 21,
issue 1
页码: 1-13
ISSN:0362-4803
年代: 1984
DOI:10.1002/jlcr.2580210102
出版商: John Wiley&Sons, Ltd.
关键词: Phosphatidylcholines;Phosphatidylethanol amines;Phospholipid synthesis;Deuterium‐labeled fatty acid
数据来源: WILEY
摘要:
AbstractImproved reliable methods for the partial chemical synthesis of phosphatidylcholines and phosphatidylethanolamines are described. Glycerophosphorylcholine (GPC) as its cadmium chloride complex was acylated rapidly (3 hr) with deuterated acyl anhydrides in dimethylformamide (DMF) to give phosphatidylcholines in>90% yields. The products were free ofsn‐1 andsn‐2 isomers. 2‐Lysophosphatidylcholines were rapidly acylated with acyl anhydrides, used in nearly stoichiometric amounts, in chloroform affording mixed‐chain phosphatidylcholines in>85% yield. Pure phosphatidylethanolamines are prepared routinely in>70% yield by an improved procedure from the corresponding phospatidylcholines using phosphol
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