In vivo Evaluation of the Stratum corneum Barrier Function in Blacks, Caucasians and Asians with Two Noninvasive Methods
作者:
F. Kompaore,
J.P. Marty,
Ch. Dupont,
期刊:
Skin Pharmacology and Physiology
(Karger Available online 1993)
卷期:
Volume 6,
issue 3
页码: 200-207
ISSN:1660-5527
年代: 1993
DOI:10.1159/000211136
出版商: S. Karger AG
关键词: Transepidermal water loss;Laser Doppler velocimetry;Stripping;Skin permeability;Races;Cutaneous blood flow
数据来源: Karger
摘要:
This study compared in man the in vivo barrier function of stratum corneum in three racial groups: black, Caucasian and Asian, by two noninvasive technics. They were transepidermal water loss (TEWL) determination measured with an evaporimeter and laser Doppler velocimetry (LDV) to measure the lag time before the vasodilatation induced by application of methyl nicotinate (10 μl of 0.5% solution in ethanol/propylene glycol 95/5 v/v). Both methods were performed simultaneously on each forearm of 7 black, 8 Caucasian and 6 Asian subjects before and after removal of the stratum corneum by stripping. TEWL measurements were higher (p < 0.01) in Asians and Blacks compared to Caucasians. Stripping (8 or 12 strips) increased TEWL in all groups; TEWL increase percentage was higher (p < 0.05) in Asians compared to Caucasians. Vasodilatation lag times assessed by LDV showed that skin permeability was more important in Asians (p < 0.01) and in Caucasians (p black. Our study showed that, with both noninvasive methods, removal of the stratum corneum increased permeability, with racial differences
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