Influence of Long-Term Treatment of the Rat with Clebopride on the Morphology of the Mammary Gland
作者:
Thereza C.M. de Lima,
Gina S. Morato,
Selma Loch,
Davi R. Tames,
期刊:
Pharmacology
(Karger Available online 1990)
卷期:
Volume 40,
issue 1
页码: 54-59
ISSN:0031-7012
年代: 1990
DOI:10.1159/000138639
出版商: S. Karger AG
关键词: Clebopride;Substituted benzamides;Mammary glands
数据来源: Karger
摘要:
The substituted benzamides or orthopramides are used to treat gastrointestinal and psychotic disorders. The orthopramide clebopride, a potent dopaminergic antagonist, blocks emesis in dogs and stereotyped behavior in rodents. Since the release of prolactin is inhibited by dopamine, antidopaminergic drugs may be useful to increase lactation in nursing mothers. The present work examines the morphological and histological alterations produced by long-term treatment of puerperal and virgin female rats with clebopride. Clebopride induced significant hyperplasia of parenchymal secretory units and stimulated milk secretion in both groups of rats. However, only in virgin rats was mammary weight significantly increased.
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