Positive CD 17 Myeloid Antigen in Acute Leukemia Expressing Lymphoid Antigens: Abnormal Genomic Processes in Multiphenotypic Leukemia or New Subtypes within Lymphoid Leukemia?
作者:
PhilipPatrick J. M.,
BaudouinFrancoise,
SudakaIsabelle,
BayleJacques,
期刊:
Leukemia&Lymphoma
(Taylor Available online 1993)
卷期:
Volume 11,
issue 5-6
页码: 473-476
ISSN:1042-8194
年代: 1993
DOI:10.3109/10428199309067943
出版商: Taylor&Francis
关键词: CD17;myeloid antigens;acute leukemia lymphoid antigens;multiphenotypic leukemia
数据来源: Taylor
摘要:
Specific morphological and histochemical changes serve to define stages of differentiation during terminal myeloid maturation. The development of the hybridoma technology has allowed generation of monoclonal antibodies selectively reactive with antigenic determinants expressed in the hematopoietic system by myeloid cells at specific stages of differentiation. Here, the characterization by one of these antibodies i.e. GO35 (CD17) which shows myeloid specificity, was reported on blastic cells from 30% of acute lymphoid leukemia cases investigated (8/25). This monoclonal antibody may prove useful in the subclassification of atypical lymphoproliferative disorders including“hybrid leukemias”and serve as a possible prognostic factor for a therapy.
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