首页   按字顺浏览 期刊浏览 卷期浏览 Selective delivery of etoposide to intraperitoneal tissues using a new dosage format&co...
Selective delivery of etoposide to intraperitoneal tissues using a new dosage format: etoposide microcrystals suspended in oil

 

作者: Akeo Hagiwara,   Toshio Takahashi,   Masaki Lee,   Chouhei Sakakura,   Satoshi Shoubayashi,   Shigeru Tashima,   Akira Yamamoto,   Shozo Muranishi,  

 

期刊: Anti-Cancer Drugs  （OVID Available online 1993）
卷期: Volume 4, issue 1  

页码: 27-31

 

ISSN:0959-4973

 

年代: 1993

 

出版商: OVID

 

关键词: Drug delivery system;drug distribution;ETOP-OIL;etoposide;intraperitoneal administration

 

数据来源: OVID

 

摘要:

Rats received an intraperitoneal bolus injection of etoposide at 5 mg/kg of body weight in the form of an etoposide microcrystal suspension in oil (ETOP-OIL) or an aqueous etoposide solution. The tissue distribution was subsequently analyzed using high performance liquid chromatography. ETOP-OIL delivered significantly greater amounts of etoposide and for a longer duration to the intraperitoneal tissues such as the omentum and the spleen, whereas it delivered significantly less etoposide to the rest of the body such as the lung, the heart and the bone marrow, than the aqueous etoposide solution.

 

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