How orally administered terbinafine reaches the stratum corneum
作者:
LeverLr,
DykesPj,
ThomasR,
FinlayAy,
期刊:
Journal of Dermatological Treatment
(Taylor Available online 1990)
卷期:
Volume 1,
issue sup2
页码: 23-25
ISSN:0954-6634
年代: 1990
DOI:10.3109/09546639009089026
出版商: Taylor&Francis
数据来源: Taylor
摘要:
The route of terbinafine (Lamisil) penetration into the stratum corneum after oral administration was studied in five patients. Serial skin surface biopsy samples of stratum corneum were taken after 1, 3, 7 and 14 days of treatment and terbinafine levels measured by high-performance liquid chromatography. Terbinafine was detected in the stratum corneum as early as 24 hours after the start of treatment in three of five patients. In all cases terbinafine was first detected in the deeper levels of stratum corneum, indicating that the route of delivery to stratum corneum after oral administration is initially by epidermal diffusion.
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