Production of Monoclonal Antibodies against the N-Terminal Noncollagenous Domain of Type VII Collagen Encoded by Epidermolysis bullosa acquisita Antigen cDNA
作者:
T. Tanaka,
N. Matsuyoshi,
F. Furukawa,
S. Imamura,
期刊:
Dermatology
(Karger Available online 1994)
卷期:
Volume 189,
issue 1
页码: 42-45
ISSN:1018-8665
年代: 1994
DOI:10.1159/000246927
出版商: S. Karger AG
关键词: Monoclonal antibody;Collagen type VII;Epidermolysis bullosa acquisita;Bullous disease
数据来源: Karger
摘要:
Eleven monoclonal antibodies were produced against the human N-terminal noncollagenous domain of type VII collagen. All antibodies were specifically bound to the epidermal basement membrane zone and did not cross-react with other dermal collagens. A binding of these antibodies was investigated with various species and revealed that the reactivities of each monoclonal antibody against rat, mouse, human and guinea pig skin differ from each other. These data may suggest that type VII collagen is antigenic to immunized small animals, i.e. the rat and mouse, and that threre are multiple antigenic determinants on type VII collagen.
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