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A Switch from Propofol to Etomidate During an ECT Course Increases EEG and Motor Seizure Duration

 

作者: Cornelis Stadtland,   Andreas Erfurth,   Ulrich Ruta,   Nikolaus Michael,  

 

期刊: The Journal of ECT  (OVID Available online 2002)
卷期: Volume 18, issue 1  

页码: 22-25

 

ISSN:1095-0680

 

年代: 2002

 

出版商: OVID

 

关键词: Electroconvulsive therapy;Seizure duration;Propofol;Etomidate

 

数据来源: OVID

 

摘要:

IntroductionOf 58 patients treated at our electroconvulsive therapy (ECT) unit early in the year 2000, 12 patients under propofol did not achieve a seizure duration of >30 s [electroencephalogram (EEG)] with a maximum stimulation charge of 504.0 mC (100%).MethodA switch from propofol to etomidate was therefore undertaken in these patients at the next treatment to achieve longer seizure duration.ResultsIn 11 of the 12 patients, a remarkable increase in seizure duration was recorded after the change of anesthetic. The mean seizure duration increased from 18.6 to 43.4 s and remained at that level for the following ECT session. The increase was highly significant (t11= 3.772, p < 0.001). The mean motor seizure also changed from 11.6 to 27.5 s (t11= 5.560, p < 0.003) and remained there for the next treatment.DiscussionOur data show that the switch more than doubles EEG seizure duration and suggest that etomidate can be used instead of methohexital as an alternative in patients with short seizure duration. It is also a potential option to avoid the pain frequently associated with the injection of propofol.

 

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