Regional Variation of Nonimmunologic Contact Urticaria
作者:
David L. Shriner,
Howard I. Maibach,
期刊:
Skin Pharmacology and Physiology
(Karger Available online 1996)
卷期:
Volume 9,
issue 5
页码: 312-321
ISSN:1660-5527
年代: 1996
DOI:10.1159/000211433
出版商: S. Karger AG
关键词: Contact irritation;Benzoic acid;Blood flow;cutaneous;Transepidermal water loss;Stratum corneum hydration;Temperature;pH
数据来源: Karger
摘要:
Background and Design: Benzoic acid (BA) was used to induce nonimmunologic contact irritation in 10 younger (23-47 years old) and 5 older (72-90 years old) healthy volunteers. BA2.5% in petrolatum was applied to 8 locations on the face, neck and volar forearm. Changes in the skin blood flow were monitored using a laser Doppler flowmeter. Also measured at each location were baseline measurements of skin blood flow, transepidermal water loss, stratum corneum hydration, skin surface temperature and skin surface pH. Results: The neck area exhibited the greatest reaction in both age groups while the forearm exhibited the least. At each site tested, the younger group consistently demonstrated greater reactivity to BA. A significant correlation was noted between stratum corneum hydration and irritation. Conclusion: This information provides a basis to further study the frequent poorly understood intolerance of the face to topical formulation.
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