Orthostatic Effect of Imipramine and Doxepin inDepressed Geriatric Outpatients
作者:
ROBERT NESHKES,
ROBERT GERNER,
LISSY JARVIK,
JIM MINTZ,
JEFFREY JOSEPH,
SHIRLEY LINDE,
JEANNE ALDRICH,
MATTHEW CONOLLY,
RICHARD ROSEN,
MARYANN HILL,
期刊:
Journal of Clinical Psychopharmacology
(OVID Available online 1985)
卷期:
Volume 5,
issue 2
页码: 102-108
ISSN:0271-0749
年代: 1985
出版商: OVID
数据来源: OVID
摘要:
Blood pressure measurements were collected from 36 depressed geriatric outpatients (ages 55 to 81 years) enrolled in a double-blind, placebo-controlled study of the efficacy of doxepin and imipramine. Mean systolic postural changes were 25.9 mm Hg for imipramine, significantly higher than the 10.5 mm Hg for doxepin, and 12.4 mm Hg for placebo. The orthostatic drop in the imipramine group was only weakly related to dose and did not correlate with amount of pretreatment orthostatic hypotension or with duration of treatment. The increased orthostatic hypotension occurred early in treatment and at low doses of imipramine. Accordingly, caution is advised in the use of imipramine for the elderly.
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