首页   按字顺浏览 期刊浏览 卷期浏览 Effect of Ciclosporin A on Epidermal Keratinocytes in vitro: Lack of a Direct Effect on...
Effect of Ciclosporin A on Epidermal Keratinocytes in vitro: Lack of a Direct Effect on Calmodulin

 

作者: Janet A. Fairley,   Peter D. Fung,   Nancy M. Ewing,  

 

期刊: Skin Pharmacology and Physiology  （Karger Available online 1990）
卷期: Volume 3, issue 3  

页码: 149-156

 

ISSN:1660-5527

 

年代: 1990

 

DOI:10.1159/000210864

 

出版商: S. Karger AG

 

关键词: Ciclosporin;Calmodulin;Epidermal keratinocytes;Proliferation

 

数据来源: Karger

 

摘要:

Calmodulin, a major calcium-binding protein, is important in the regulation of cell proliferation. In human keratinocytes we found that culture confluence was accompanied by a decrease in calmodulin content. Ciclosporin A, 1–10 μg/ml, was found to inhibit the proliferation of the cells but did not affect their calmodulin content as measured by bioassay or radioimmunoass

 

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