Multidrug resistance: Drug extrusion and its counteraction by chemosensitizers
作者:
E. Friche,
T. Skovsgaard,
K. Danø,
期刊:
European Journal of Haematology
(WILEY Available online 1989)
卷期:
Volume 42,
issue S48
页码: 59-67
ISSN:0902-4441
年代: 1989
DOI:10.1111/j.1600-0609.1989.tb01239.x
出版商: Blackwell Publishing Ltd
关键词: multidrug resistance;chemosensitizers;an‐thracyclines;vinca alkaloids
数据来源: WILEY
摘要:
Multidrug resistance involves cross‐resistance between some of the most important agents in cancer chemotherapy, including the anthracyclines and the vinca alkaloids. It is closely related to an active extrusion of the drugs from the resistant cells, which is related to an overexpression of the multidrug resistance gene encoding a membrane protein, the P‐glycoprotein, that has homologies with bacterial transport proteins. The extrusion mechanism is accessible to inhibition by several means, and particularly the use of competitive inhibition with non‐toxic analogues of the drugs has proved to be an effective way to reverse multidrug resistance in animal tumorsin
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