2-Deoxyglycosyl Phosphorodithioates. A Novel Type of Glycosyl Donor. Efficient Synthesis of 2'-Deoxydisaccharides
作者:
Halszka Bielawska,
Maria Michalska,
期刊:
Journal of Carbohydrate Chemistry
(Taylor Available online 1991)
卷期:
Volume 10,
issue 1
页码: 107-112
ISSN:0732-8303
年代: 1991
DOI:10.1080/07328309108543896
出版商: Taylor & Francis Group
数据来源: Taylor
摘要:
The occurrence of 2'-deoxydisaccharides as structural units of a number of biologically important natural products explains the efforts involved in their synthesis.1The majority of the reported procedures is based on addition reactions to glycals leading to 2-deoxyglycosyl donors which can be directly condensed with sugar aglycones yielding 2'-deoxydisaccharides or to glycosylating reagents with a “cryptodeoxy” function, which is removed under mild conditions after the formation of the glycosidic linkage. The main disadvantage of 2-deoxyglycosyl donors such as 2-deoxyglycosyl halides, is their chemical and configurational instability.
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