&NA;Vulvovaginal candidiasis is a miserable infection that affects millions of women each year. The purpose of this article's study was to investigate the effectiveness of an immediate treatment intervention for increasing the comfort level of women with vulvovaginal candidiasis. An experimental study using a sample of 20 women compared the comfort of a control group, which received routine care, to the comfort of the experimental group, which received routine care plus vaginal debridement followed by application of vaginal medication. The experimental group experienced greater relief from their symptoms post‐treatment than did the control group. Implications for NP practice are presented.