Neurturin protects dopaminergic neurons following medial forebrain bundle axotomy
作者:
Jack Tseng,
Suzanne Bruhn,
Anne Zurn,
Patrick Aebischer,
期刊:
NeuroReport
(OVID Available online 1998)
卷期:
Volume 9,
issue 8
页码: 1817-1822
ISSN:0959-4965
年代: 1998
出版商: OVID
关键词: MFB axotomy;Neurturin;Parkinson's disease;Polymer encapsulation;Substantia nigra;Tyrosine hydroxylase
数据来源: OVID
摘要:
TO determine whether neurturin (NTN), a recently identified homologue of glial cell line-derived neurotrophic factor (GDNF), is able to preserve tyrosine hydroxylase immunoreactivity (TH-IR) in a rat model of Parkinson's disease, polymer encapsulated cells genetically engineered to release NTN were implanted near the substantia nigra 1 week before a unilateral medial forebrain bundle axotomy. Animals were allowed to survive for 1 week post-axotomy. Upon sacrifice, animals that received a NTN capsule had a significantly higher percentage of TH-IR (lesioned sidevsnon-lesioned side) than animals that had received a capsule containing nontransfected parent cells. However, in contrast to GDNF, no reduction of turning was observed upon amphetamine rotation with NTN. Nevertheless, these results suggest that NTN might have a therapeutic value for the treatment of Parkinson's disease.
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