Aneuploidy with Neural Tube Defects: Another Reason for Complete Evaluation in Patients with Suspected Ultrasound Anomalies or Elevated Maternal Serum Alpha-Fetoprotein
作者:
Arie Drugan,
Mark Paul Johnson,
Elaina Dvorin,
Joyce Moody,
Eric L. Krivchenia,
David Schwartz,
Mark I. Evans,
期刊:
Fetal Diagnosis and Therapy
(Karger Available online 1989)
卷期:
Volume 4,
issue 2-3
页码: 88-92
ISSN:1015-3837
年代: 1989
DOI:10.1159/000263429
出版商: S. Karger AG
关键词: Neural tube defects;Aneuploidy;α-Fetoprotein
数据来源: Karger
摘要:
Some recent reports have suggested that invasive testing is unnecessary when ultrasound either confirms or refutes a neural tube defect (NTD). However, counseling for recurrence risks and the possibilities for in utero therapy would be significantly altered by an aneuploid karyotype. We report our experience with 53 pregnancies affected by NTD in which we found 13.2% of these fetuses with abnormal chromosomes. In view of the higher than previously published incidence of aneuploidy, we.believe that fetal karyotypes are essential in the evaluation of all fetuses with NTDs.
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