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Aneuploidy with Neural Tube Defects: Another Reason for Complete Evaluation in Patients with Suspected Ultrasound Anomalies or Elevated Maternal Serum Alpha-Fetoprotein

 

作者: Arie Drugan,   Mark Paul Johnson,   Elaina Dvorin,   Joyce Moody,   Eric L. Krivchenia,   David Schwartz,   Mark I. Evans,  

 

期刊: Fetal Diagnosis and Therapy  (Karger Available online 1989)
卷期: Volume 4, issue 2-3  

页码: 88-92

 

ISSN:1015-3837

 

年代: 1989

 

DOI:10.1159/000263429

 

出版商: S. Karger AG

 

关键词: Neural tube defects;Aneuploidy;α-Fetoprotein

 

数据来源: Karger

 

摘要:

Some recent reports have suggested that invasive testing is unnecessary when ultrasound either confirms or refutes a neural tube defect (NTD). However, counseling for recurrence risks and the possibilities for in utero therapy would be significantly altered by an aneuploid karyotype. We report our experience with 53 pregnancies affected by NTD in which we found 13.2% of these fetuses with abnormal chromosomes. In view of the higher than previously published incidence of aneuploidy, we.believe that fetal karyotypes are essential in the evaluation of all fetuses with NTDs.

 

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