Cocaine Exposure During PregnancyImproving Assessment With Radioimmunoassay of Maternal Hair
作者:
THERESE GRANT,
ZANE BROWN,
CHARLES CALLAHAN,
HELEN BARR,
ANN STREISSGUTH,
期刊:
Obstetrics & Gynecology
(OVID Available online 1994)
卷期:
Volume 83,
issue 4
页码: 524-531
ISSN:0029-7844
年代: 1994
出版商: OVID
数据来源: OVID
摘要:
Objective:To compare radioimmunoassay of postpartum maternal hair samples with a structured maternal interview for the detection of cocaine use during pregnancy.Methods:Radioimmunoassay of hair samples obtained postpartum was compared with self‐report of cocaine use obtained by confidential, structured interviews of 405 postpartum women.Results:Cocaine or benzoylecgonine was detected in the hair samples of 129 of the 148 women (87%) who reported using cocaine at least once during pregnancy. Thirty‐six of 257 women (14%) who reported that they had used no cocaine during pregnancy had positive hair tests. Positive hair assay with negative self‐report was significantly more common among women who were unmarried (P= .001), African‐American (P< .001), and multiparous (P= .035).Conclusions:Hair analysis is a valuable complement to maternal self‐report by interview. The methods used together provide a useful clinical and research technique yielding a comprehensive estimate of gestational cocaine exposure. Either method alone may result in misclassification of gestational cocaine exposure.(Obstet Gynecol 1994;83:524‐31)
点击下载:
PDF
(6975KB)
返 回