Beta-2-Microglobulin-Associated Amyloidosis
作者:
Jürgen Floege,
Götz Ehlerding,
期刊:
Nephron
(Karger Available online 1996)
卷期:
Volume 72,
issue 1
页码: 9-26
ISSN:1660-8151
年代: 1996
DOI:10.1159/000188801
出版商: S. Karger AG
关键词: Beta-2-microglobulin;Amyloidosis;Renal failure;Hemodialysis Peritoneal dialysis
数据来源: Karger
摘要:
β2-Microglobulin-associated amyloidosis has emerged as a major complication of long-term renal replacement therapy. The syndrome is confined to those patients on nontransplant modes of therapy. It does not occur in patients with a functioning renal transplant or, if already present, it does not progress any further in such patients. In the population of ESRD patients on dialysis, β2-microglobulin-associated amyloidosis affects most patients treated for more than 15 years and is a cause of significant morbidity and in rare cases even mortality. The present review, which is based on the presentation of a typical case, discusses the current knowledge on the pathogenesis, clinical manifestations, diagnosis, prevention and therapy of β2-microblobulin-associated amyloidos
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