The Murine Mutation Trembler-J: Proof of Semidominant Expression by Use of the Linked Vestigial Tail Marker
作者:
HenryEarl Webb,
SidmanRichard L.,
期刊:
Journal of Neurogenetics
(Taylor Available online 1983)
卷期:
Volume 1,
issue 1
页码: 39-52
ISSN:0167-7063
年代: 1983
DOI:10.3109/01677068309107071
出版商: Taylor&Francis
关键词: myelin sheath;pathology;neurological mutants;peripheral nerve;pathology;Schwann cells;pathology;trembler-J allele;vestigial tail;mouse
数据来源: Taylor
摘要:
Trembler-J,TrJ, is a peripheral hypomyelinating murine mutant. In intercrosses(TrJ/+ xTrJ/ +) there are severely affected (behaviorally and pathologically), mildly affected, and normal offspring, while back-crosses(TrJ/+ x + /+) produce only mildly affected and normal offspring. We used the closely linked marker vestigial tail,vt, to test whether severely affected offspring of intercrosses(TrJvt/+ + xTrJvt/+ +) wereTrJ/ TrJ.In 5/6 intercrosses all severely affected animals were short-tailed and vice versa, while all mildly affected animals had long tails and vice versa. It is highly probable that the severely affected, mildly affected, and normal classes of intercross offspring were ofTrJ/ TrJ, TrJ/+, and + / + genotypes, respectively.
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