Increased Prevalence of Vulvovaginal Condyloma and Vulvar Intraepithelial Neoplasia in Women Infected With the Human Immunodeficiency Virus
作者:
MARY CHIASSON,
TEDD ELLERBROCK,
TIMOTHY BUSH,
XIAO-WEI SUN,
THOMAS WRIGHT,
期刊:
Obstetrics & Gynecology
(OVID Available online 1997)
卷期:
Volume 89,
issue 5, Part 1
页码: 690-694
ISSN:0029-7844
年代: 1997
出版商: OVID
数据来源: OVID
摘要:
ObjectiveTo compare the prevalence of human papilloma-virus (HPV)-associated vulvovaginal lesions in human immunodeficiency virus (HIV)-positive and HIV-negative women.MethodsFor this cross-sectional study, all participants received a complete gynecologic examination including colposcopic evaluation and a structured interview about sociodemographic characteristics and risk factors for vulvovaginal disease. In addition, HPV DNA was assayed for in cervicovaginal lavages using polymerase chain reaction.ResultsVulvar and/or vaginal condyloma acuminata were detected in 22 of 396 (5.6%) HIV-positive and in 3 of 375 (0.8%) HIV-negative women (odds ratio [OR] 7.3,P< .001). High-grade vulvar intraepithelial neoplasia (VIN) was present in two of the HIV-positive and none of the HIV-negative women. Human immunodeficiency virus-positive women with condyloma or VIN were significantly more likely to have cervical intraepithelial neoplasia (33%) than those without vulvovaginal lesions (17%) (OR 2.9, 95% confidence interval [CI] 1.1, 74). In multivariate logistic regression analysis, both HIV seropositivity (adjusted OR 5.3, 95% CI 1.3, 35.3) and HPV infection (adjusted OR 6.1, 95% CI 1.7, 39.4) were associated with vulvovaginal condyloma.ConclusionThe prevalence of vulvovaginal condyloma was increased in HIV-positive women even when controlling for HPV infection. Human papillomavirus-associated disease was more likely to be multicentric and involve the vulva, vagina, and cervix in HIV-positive than HIV-negative women. Detection of high-grade VIN in two of the HIV positive women suggests that they may also be at risk for developing invasive vulvar carcinoma.
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