Induction of Murine Macrophage Growth by Modified LDLs
作者:
Satoru Yui,
Toshinori Sasaki,
Akira Miyazaki,
Seikoh Horiuchi,
Masatoshi Yamazaki,
期刊:
Arteriosclerosis and Thrombosis: A Journal of Vascular Biology
(OVID Available online 1993)
卷期:
Volume 13,
issue 3
页码: 331-337
ISSN:1049-8834
年代: 1993
出版商: OVID
关键词: macrophage growth;acetylated LDL;oxidized LDL;scavenger receptors
数据来源: OVID
摘要:
We previously reported that cell membrane components and lipoproteins were able to induce the growth of murine peritoneal macrophages. The aim of the present study was to examine whether macrophage growth could also be induced by chemically modified lipoproteins, such as acetylated low density lipoprotein (acetyl-LDL) or oxidized LDL, ligands known to be endocytosed by the macrophage scavenger receptors. When murine peritoneal exudate macrophages were cultured in vitro with 25-100 ju.g/mL acetyl-LDL or oxidized LDL, significant growth was induced. On comparing the dose—response curves of these LDLs, a more potent effect was seen with oxidized LDL than acetyl-LDL, especially on resident macrophages. On the other hand, growth of these cells was not stimulated by native (unmodified) LDL or high density lipoprotein. These in vitro data revealed a new function of chemically modified LDLs as effective inducers of macrophage cell growth. This aspect may be physiologically relevant to the growth of macrophage foam cells in situ in the development of atherosclerosis.
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