Carbamazepine blocks NMDA‐activated currents in cultured spinal cord neurons
作者:
Hansjörg,
Lampe Hans,
期刊:
NeuroReport
(OVID Available online 1990)
卷期:
Volume 1,
issue 1
页码: 26-28
ISSN:0959-4965
年代: 1990
出版商: OVID
关键词: Carbamazepine;Phenytoin;Cultured neurons;Epilepsy;NMDA receptor;Voltage clamp;Whole cell recording;Anticonvulsant
数据来源: OVID
摘要:
THE antiepileptic agents, carbamazepine and phenytoin, suppress seizures in man and convulsant-induced hyper-activity in spinal cord nerve cell cultures. In the present study, we have shown by whole cell recording that carbamazepine, in contrast to phenytoin, blocks N-methyl-D-aspartate (NMDA)-activated membrane currents in cultured neurons in a dose-dependent fashion. The NMDA receptor-activated channel, which is blocked at physiological concentrations of Mg2+at resting membrane potential, can be activated by glutamate in depolarized neurons and thus be involved in epileptogenesis. Therefore, the block of NMDA-evoked membrane currents in cultured neurons may contribute to the clinical effectiveness of carbamazepine.
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