Potential of β2-Adrenoceptor Agonists as Add-On Therapy for Multiple SclerosisFocus on Salbutamol (Albuterol)
作者:
Karim Makhlouf,
Howard L. Weiner,
Samia J. Khoury,
期刊:
CNS Drugs
(ADIS Available online 2002)
卷期:
Volume 16,
issue 1
页码: 1-8
ISSN:1172-7047
年代: 2002
出版商: ADIS
关键词: Beta 2 adrenoceptor agonists, therapeutic use;Multiple sclerosis, treatment;Salbutamol, general
数据来源: ADIS
摘要:
The β2-adrenergic receptor agonist salbutamol (albuterol) has been used for many years in the treatment of bronchospasm in patients with asthma. In this patient group, salbutamol is a relatively safe and inexpensive drug, and is easy to administer.Within the last few years, there has been increasing evidence that salbutamol might have immunomodulatory properties bothin vitroandin vivo, in different animal models as well as in humans. This has led researchers to consider salbutamol as a potential therapy for several autoimmune diseases, including multiple sclerosis (MS).In this article, we review the literature presenting such evidence, and discuss the possible mechanisms by which salbutamol influences the immune system. We conclude that salbutamol might be an interesting add-on therapy in patients with MS and that further research is warranted.
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