Noradrenergic Afferents Facilitate the Activity of Tuberoinfundibular Neurons of the Hypothalamic Paraventricular Nucleus
作者:
Trevor A. Day,
Alastair V. Ferguson,
Leo P. Renaud,
期刊:
Neuroendocrinology
(Karger Available online 1985)
卷期:
Volume 41,
issue 1
页码: 17-22
ISSN:0028-3835
年代: 1985
DOI:10.1159/000124148
出版商: S. Karger AG
关键词: Tuberoinfundibular neurons;Paraventricular nucleus;A1 noradrenergic neurons;A2 noradrenergic neurons;Caudal medulla;6-Hydroxydopamine;Electrophysiology
数据来源: Karger
摘要:
The role of ascending noradrenergic projections of medullary origin in regulating the activity of tuberoinfundibular neurons of the hypothalamic paraventricular nucleus (PVN) was examined in pentobarbital-anesthetized male Sprague-Dawley rats. Discrete electrical stimulation of either the Al or the A2 noradrenaline cell group areas of the caudal medulla enhanced the probability of firing in a substantial proportion of antidromically identified tuberoinfundibular PVN cells tested. Notably, no inhibitory effects were observed. Destruction of the PVN noradrenergic terminal plexus by local application of the neurotoxin 6-hydroxydopamine 1 day prior to electrophysiological experiments abolished the effects of both Al and A2 stimulation. These findings indicate that noradrenergic afferents can exert a facilitatory influence on the activity of a population of tuberoinfundibular PVN neurons, thus supporting earlier suggestions that central noradrenergic structures can enhance the release of certain anterior pituitary hormones.
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