Angiotensin II Signaling in Vascular Smooth MuscleNew Concepts
作者:
Kathy K. Griendling,
Masuko Ushio-Fukai,
Bernard Lassegue,
R. Wayne Alexander,
期刊:
Hypertension
(OVID Available online 1997)
卷期:
Volume 29,
issue 1
页码: 366-373
ISSN:0194-911X
年代: 1997
出版商: OVID
数据来源: OVID
摘要:
Angiotensin II is a multifunctional hormone that affects both contraction and growth of vascular smooth muscle cells through a complex series of intracellular signaling events initiated by the interaction of angiotensin II with the AT1receptor. The cellular response to angiotensin II is multiphasic, involving stimulation within seconds of phospholipase C and Ca2+mobilization; activation within minutes of phospholipase D, A2, protein kinase C, and MAP kinase; and stimulation after a period of hours of gene transcription and NADH/NADPH oxidase activity. Angiotensin II also activates numerous intracellular tyrosine kinases. In this respect, it shares some aspects of signaling with growth factor and cytokine receptors, including activation of phospholipase C-gamma, src, and ras; association of shc with grb2; and stimulation of the Jak/STAT pathway. The cellular events responsible for this unique series of events may involve receptor movement and the creation of a signaling domain. Elucidation of these pathways is important to our understanding of AT1receptor function as a final effector of the renin-angiotensin system. (Hypertension. 1997;29[part 2]:366-373.)
返 回