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Analysis of GABAAreceptor subunit genes in multiplex pedigrees with manic depression

 

作者: H. Coon,   A. Hicks,   M. Bailey,   M. Hoff,   J. Holik,   R. Harvey,   K. Johnson,   M. Darlison,   F. Reimherr,   P. Wender,   W. Byerley,  

 

期刊: Psychiatric Genetics  （OVID Available online 1994）
卷期: Volume 4, issue 3  

页码: 185-191

 

ISSN:0955-8829

 

年代: 1994

 

出版商: OVID

 

关键词: GABAAreceptor genes;Linkage analysis;Manic depression

 

数据来源: OVID

 

摘要:

The gamma-aminobutyric acid (GABA) neurotransmitter system has been implicated in the pathogenesis of manic depression. Tests of this hypothesis can now be carried out due to the recent characterization of simple sequence repeat polymorphisms for the GABAAreceptor α1, α2, α4, α5, α6, β1, β3 and γ2 subunit genes. Using both parametric and non-parametric methods, we tested for linkage between manic depression and these polymorphisms in six multi-generational pedigrees. No evidence of linkage was found.

 

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