BackgroundShortening of the anterograde effective refractory period (ERP) of the fast pathway has been reported after radiofrequency ablation of the slow pathway. We hypothesized that ERP shortening may be related to autonomic changes, possibly catecholamine release, as a result of ablation.Methods and ResultsTo test this, 10 consecutive patients with atrioventricular node reentry undergoing slow pathway ablation were given autonomic blockade before the ablation procedure. This was achieved by atropine 0.03 mg/kg and propranolol 0.15 mg/kg IV supplemented by half the initial dose after ablation and before the final study. A control group of 10 patients underwent the protocol without autonomic blockade. Before ablation, autonomic blockade did not alter the ERP of either the fast pathway (295±22 versus 298±26 milliseconds) or the slow pathway (264±36 versus 269±38 milliseconds). Autonomic blockade obscured dual pathway physiology in 2 patients and brought it out in another 2 without dual pathway physiology initially. Slow pathway ablation shortened the ERP of the fast pathway for the group as a whole (331.5±54 versus 305.5±60 milliseconds, mean±SD,n= 20,P< .04). There was no difference in degree of ERP shortening in control patients (23.5±58 milliseconds) or autonomic blockade patients (25.5±52 milliseconds).ConclusionsThese data suggest that shortening of the ERP of the fast pathway after slow pathway ablation is not mediated by autonomic changes.