Renal Lesions of the FGS Strain of Mice: A Spontaneous Animal Model of Progressive Glomerulosclerosis
作者:
Futoshi Yoshida,
Seiichi Matsuo,
Hiroshi Fujishima,
Hyun-Ki Kim,
Takeshi Tomita,
期刊:
Nephron
(Karger Available online 1994)
卷期:
Volume 66,
issue 3
页码: 317-325
ISSN:1660-8151
年代: 1994
DOI:10.1159/000187830
出版商: S. Karger AG
关键词: Animal model;Mouse;Glomerulosclerosis;Proteinuria
数据来源: Karger
摘要:
The strain of FGS/Nga mouse is reported to develop proteinuria and progressive glomerulosclerosis. We studied the renal pathology of that strain periodically for 1 year. Focal and segmental glomerulosclerosis was observed 3 months after birth and the lesion progressed to the glomerular obsolescence in a year. Electron microscopic study revealed electron dense deposits (DD) in the mesangium and the splitting of glomerular basement membrane. Studies using immunofluorescence and immunoelectron microscopy revealed that these DD were contained IgA, IgM, C3 and the retroviral envelope antigen (gp70). Clinically, proteinuria began at the age of 3 months and the renal function was decreased on time course. No other organs were involved. We studied the renal lesions of FGS mice by the histological and immunohistochemical methods and concluded that this mouse strain provides the tool for studying the mechanisms of the progression of glomerulosclerosis.
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