THE EFFECT OF DOPAMINE ON TRACHEAL SMOOTH MUSCLE
作者:
M. C. Michoud,
R. Amyot,
S. St‐Jean,
R. Vaillancourt,
期刊:
Clinical and Experimental Pharmacology and Physiology
(WILEY Available online 1985)
卷期:
Volume 12,
issue 1
页码: 51-59
ISSN:0305-1870
年代: 1985
DOI:10.1111/j.1440-1681.1985.tb00302.x
出版商: Blackwell Publishing Ltd
关键词: bronchomotor tone;catecholamines;dog;dopamine;guinea‐pig;human;trachea.
数据来源: WILEY
摘要:
SUMMARY1. Dose‐response curves to dopamine were obtained on guinea‐pig, dog and human tracheal smooth muscle.2. Dopamine produced a relaxation of the guinea‐pig tracheal chain, and this relaxation was completely blocked by propranolol. The potency of dopamine as a β‐agonist was 1/10 000 that of isoprenaline, 1/250 that of adrenaline and 1/50 that of noradrenaline.3. In human and dog tracheal smooth muscle, dopamine induced a contraction which could be entirely abolished by α‐adrenoceptor antagonists. As an α‐agonist, the potency of dopamine was 1/20 that of adrenaline and noradrenaline.4. Our data also show that a dopamine induced contraction is greatly potentiated if the smooth muscle specimen has been previously slightly contracted with histamine.5. We conclude that there are few, if any, specific dopaminergic receptors in the airways. Dopamine acts on both α‐ and β‐adrenoceptors, but in humans and dogs, its effect is predominantl
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