In utero Surfactant Administration to Preterm Human Fetuses using Endoscopy
作者:
Boris M. Petrikovsky,
Andrzej Lysikiewicz,
Leonid B. Markin,
Zbigniew Slomko,
期刊:
Fetal Diagnosis and Therapy
(Karger Available online 1995)
卷期:
Volume 10,
issue 2
页码: 127-130
ISSN:1015-3837
年代: 1995
DOI:10.1159/000264218
出版商: S. Karger AG
关键词: Fiberoptic endoscopy;Surfactant;In utero therapy;Preterm labor
数据来源: Karger
摘要:
Our purpose was to assess the feasibility of the endoscopic delivery of surfactant directly to the fetus during active preterm labor. A gassterilized intraoperative fiberscope was introduced through the cervical canal into the amniotic cavity after spontaneous rupture of membranes during preterm labor in 3 patients. The flexible fiberscope was inserted under constant endoscopic visual control to avoid possible trauma to the fetus and the mother. Surfactant was injected into the mouths of 3 preterms fetuses through a catheter placed through the biopsy channel of the fiberscope. Fetal heart rate tracings as well as neonatal and maternal outcome are reported for each case. In utero surfactant placement was successfull in each case. The fetal heart rate remained normal throughout the procedure. No maternal or neonatal complications/infections were detected. Our preliminary experience indicates that in utero endoscopic delivery of surfactant to a preterm human fetus is feasible. The usefulness of intrapartum endoscopy in the prophylactic administration of surfactant directly to the fetus, prior to the first breath, has to be assessed in a prospective controlled study.
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