HRMAS NMR observation of β‐sheet secondary structure on a water swollen solid support
作者:
Pierre Rousselot‐Pailley,
Christophe Boutillon,
Jean‐Michel Wieruszeski,
Guy Lippens,
期刊:
Journal of Peptide Science
(WILEY Available online 2003)
卷期:
Volume 9,
issue 1
页码: 47-53
ISSN:1075-2617
年代: 2003
DOI:10.1002/psc.431
出版商: John Wiley&Sons, Ltd.
关键词: HRMAS NMR;peptide;solid phase peptide synthesis;secondary structure;intramolecular β‐sheet
数据来源: WILEY
摘要:
AbstractIn this paper HRMAS NMR was used to investigate whether peptides on a peptidyl resin swollen in aqueous solution can adopt an intramolecular β‐sheet structure. A model peptide YQNPDGSQA, that was previously shown to adopt such a secondary structure in solution, (Blancoet al., J. Am. Chem. Soc., 1993) was grafted onto three different solid supports that swell in aqueous solution to examine the influence of the resin on the structure. Both parameters of resin loading and pH inside the swollen peptidyl resin proved to be important for the physicochemical behaviour of the peptide on the support. Copyright © 2003 European Peptide Society and John Wiley&Sons,
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