Monocytes and T lymphocytes in HIV-1-positive patients express HLA-G molecule
作者:
José Lozano,
Rafael González,
José Kindelán,
Nathalie Rouas-Freiss,
Rafael Caballos,
Jean Dausset,
Edgardo Carosella,
José Peña,
期刊:
AIDS
(OVID Available online 2002)
卷期:
Volume 16,
issue 3
页码: 347-351
ISSN:0269-9370
年代: 2002
出版商: OVID
关键词: Cytotoxic T lymphocytes;HAART;HIV-1;HLA-G;IL-10;monocytes
数据来源: OVID
摘要:
ObjectiveTo study the expression of HLA-G on peripheral blood mononuclear cells (PBMC) from HIV-1-infected individuals in order to determine whether this molecule is induced as a consequence of HIV-1 infection.DesignA total of 23 HIV-positive individuals in different stages of the disease were studied.MethodsFlow cytometric analysis and Western blot were used to measure HLA-G expression on PBMC obtained from HIV-positive and control individuals.ResultsMost of the monocytes obtained from HIV-1-infected individuals express HLA-G, whereas only a very low proportion of monocytes from healthy individuals express this molecule. When T lymphocytes from HIV-1 infections were studied, it was found that 30% of them express HLA-G, whereas only 1% were HLA-G-positive in healthy individuals. HLA-G expression was also confirmed by Western blot using specific anti-HLA-G monoclonal antibodies.ConclusionThe synthesis of HLA-G is increased in monocytes and certain T lymphocytes from HIV-1-infected individuals.
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