Pharmacological Modulation by Cetirizine and Atropine of the Histamine- and Methacholine-Induced Wheals and Flares in Human Skin
作者:
D. Van Neste,
L. Ghys,
J.L. Antoine,
J.P. Rihoux,
期刊:
Skin Pharmacology and Physiology
(Karger Available online 1989)
卷期:
Volume 2,
issue 2
页码: 93-102
ISSN:1660-5527
年代: 1989
DOI:10.1159/000210806
出版商: S. Karger AG
关键词: Sweat gland activation;Wheal and flare;Anti-H1 antagonists;Atropine;Methacholine;Axon reflex;Noninvasive evaluation;Skin function;Histamine
数据来源: Karger
摘要:
This study was planned to verify whether different methods for the measurement of skin reactivity, i.e. wheal and flare area, wheal thickness, skin capacitance and transepidermal water loss, were or were not able to discriminate between intradermally injected agonists (histamine and methacholine). For evaluating agonist/antagonist interactions, we adopted a cross-over, double-blind, placebo-controlled study designed to compare the effects of cetirizine and atropine. The intradermal injection of agonists elicited the appearance of wheal and flare reactions and, after histamine, the skinfold thickness was significantly increased. Skin capacitance and transepidermal water loss measurements reflected sweat gland activation after methacholine injection but were, respectively, not or less affected by histamine dry skin prick test or saline; hence, both methods appear very sensitive for in vivo testing of cholinomimetic agents. Cetirizine inhibited all the specific skin modifications induced by histamine challenge, wheals, flares and increased thickness, without affecting the methacholine-induced perspiration. This would further support the H1 specificity of this anti-H1 agent in vivo. However, at the agonist/antagonist ratios tested in view of the safety of the test persons, we were unable to objectivate methacholine blockade by atropine.
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