Melatonin protects 6‐OHDA‐induced neuronal death of nigrostriatal dopaminergic system
作者:
Yong Kim,
Wan Joo,
Byung Jin,
Yong Cho,
Hyung Baik,
Chan Park,
期刊:
NeuroReport
(OVID Available online 1998)
卷期:
Volume 9,
issue 10
页码: 2387-2390
ISSN:0959-4965
年代: 1998
出版商: OVID
关键词: 6-Hydroxydopamine;Melatonin;Parkinson's disease;Rotational behavior;Striatum;Substantia nigra;Tyrosine hydroxylase
数据来源: OVID
摘要:
IN VIVOneuroprotective effects of melatonin on the nigrostriatal dopaminergic system in rats unilateral 6-hydroxydopamine (6-OHDA) lesions were tested. Two weeks after lesioning the dopamine receptor agonist, apomorphine produced rotational asymmetry. In contrast, melatonin treatment significantly reduced the motor deficit following apomorphine challenge. Analysis by tyrosine hydroxylase (TH) immunocytochemistry revealed the loss of cell bodies in the substantia nigra (SN) and absence of terminals in the dorsolateral striatum ipsilaterally. Melatonin treatment also resulted in the survival of dopaminergic neurons in SN and TH-immuoreactive terminals in the dorsolateral striatum. These behavioral and histochemical results may indicate a neuroprotective action of melatonin and suggest a potential pharmacological role in the treatment of Parkinson's disease.
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