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Prostacyclin, Thromboxane A2Interactions in Haemostasis and Thrombosis

 

作者: S. Moncada,   J.L. Amezcua,  

 

期刊: Pathophysiology of Haemostasis and Thrombosis  （Karger Available online 1979）
卷期: Volume 8, issue 3-5  

页码: 252-265

 

ISSN:1424-8832

 

年代: 1979

 

DOI:10.1159/000214316

 

出版商: S. Karger AG

 

关键词: Prostacyclin;Thromboxane;Haemostasis;Thrombosis

 

数据来源: Karger

 

摘要:

Prostacyclin and thromboxane A2 are products of arachidonic acid which play a role in the regulation of haemostatic plug and thrombus formation. Aspirin inhibits the synthesis of both compounds but is more active in blocking TXA2 formation; based on this, aspirin is suggested to have an anti-thrombotic effect. Other possible approaches to the development of anti-thrombotic drugs are discussed.

 

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