FK506 antagonizes apoptosis and c‐jun protein expression in neuronal cultures
作者:
C. Yardin,
F. Terro,
M. Lesort,
F. Esclaire,
J. Hugon,
期刊:
NeuroReport
(OVID Available online 1998)
卷期:
Volume 9,
issue 9
页码: 2077-2080
ISSN:0959-4965
年代: 1998
出版商: OVID
关键词: Apoptosis;cyclosporine A;C-jun;FK506;Neuronal cultures
数据来源: OVID
摘要:
FK506 is an immunosuppressive drug that binds to FK506 binding protein (FKBPs), a subgroup of cytosolic proteins called immunophillins. Previous works have revealed that FK506 protects neural cells from ischemia or excitotoxicity. Here we report that FK506 (10−6M) and not cyclosporine A (10−6M) blocks neuronal apoptosis induced by serum deprivation in rat neuronal cultures. In addition the immunohistochemical staining of C-jun protein in deprived cultures is markedly attenuated by FK506. The proportion of C-jun-positive neurons in control cultures, in serum-deprived cultures (48 h) and in serum-deprived cultures exposed to FK506 (10−6M) were 12.5%, 56.5% and 16.5%, respectively. The down-regulation of C-jun could play a major role in the anti-apoptotic action of FK506 in stressed neuronal cultures.
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